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https://www.youtube.com/watch?v=Il1cXcFOxsA
PCIE 4. 0 X16 Interface PCIE 4. 0 X16 Interface x16 slots are compatible with PCI express x8 and x16 slots
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I know this is an old post, but this info may be helpful to those who is interested in this device. The device only supports PCs that utilize PCIe bifurcation (where it can split the PCIe bus, ie: PCIe 16x will become x4/x4/x4/x4). I have tried this card on a Dell T7600, but due to the machine's lack of bifurcation only one NVMe is showing.
Bear in mind there are other options out there that do support non-bifurcation PCs, but they are costly, but I did find one called a Syba SI-PEX40142 currently going for $55 on Amazon (the company do offer M-key variants that will boot from PCIe on older systems). However this model is a B-Key variant so performance will be halved, but at the same time still faster than SATA or SAS based mechanical drives.
Company's website is: https://www.sybausa.com/index.php?route=product/product&path=64_205&product_id=1035
I did order two today and will post here if they work when I get them.
for those interested I'm posting the amazon listing below that feature all 3 variants.