Need help setting up new build please

Hello all!

I recently got a PC from my brother who had not used it in a while. I want to start using VR on it and want to maximize it's performance. My knowledge is limited, and I'd appreciate ANY advice! I am unsure how to setup the drives (startup process, where to store programs, OS, etc.). I have listed the components below, let me know if you need more info! Thanks again in advance!

Asus PRIME Z270-A MB

Intel i7-7700K CPU

GTX 980-Ti GPU

Samsung 960 Evo NVMe PCIe M.2 250GB

Crucial MX500 250GB SSD

Corsair Vengeance DDR4 2666 C16 2x8GB RAM

Windows 10